Dipartimento di Scienze Chimiche e Farmaceutiche (UniTS)
Immagine di anteprima
Direttore
Data di fondazione
2012
Sito Web
Descrizione
Il Dipartimento di Scienze Chimiche e Farmaceutiche (DSCF) dell’Università degli Studi di Trieste nasce nel 2010 dall’unione dei pre-esistenti Dipartimenti di Scienze Chimiche e di Scienze Farmaceutiche e dall’autunno 2012 svolge le funzioni didattiche delle ex-Facoltà di Scienze MMFFNN e di Farmacia relative ai corsi di laurea Triennale e Magistrale in Chimica e ai corsi a ciclo unico in Farmacia e in Chimica e Tecnologia Farmaceutiche. Il DSCF gestisce la Scuola di Dottorato in Scienze e Tecnologie Chimiche e farmaceutiche e partecipa alla scuola di Dottorato in Nanotecnologie dell’Università di Trieste. Il DSCF ospita un’importante biblioteca di chimica, numerosi laboratori didattici e di ricerca, assieme a strumentazioni e facilities dedicati alla ricerca di base ed applicata nelle varie discipline chimiche. L’attività di ricerca si articola in diversi ambiti che vanno dalla Progettazione, sintesi e formulazione di farmaci, alla Chimica supramolecolare e nanotecnologie, alla Sintesi e struttura di biomolecole, alla Chimica sostenibile e ambientale e alla Chimica teorica e computazionale, promuovendo attività di ricerca scientifica d’avanguardia con contatti scientifici a livello nazionale ed internazionale. Il Dipartimento si propone nei confronti del mondo esterno (industrie, enti di ricerca pubblici e privati, ecc.) come punto di riferimento culturale e di supporto per la ricerca chimica.
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Impostazioni
Ora in mostra 1 - 10 di 3908
  • Pubblicazione
    Conformational Sensitivity in Photoelectron Circular Dichroism of 3-Methylcyclopentanone
    ( 2013)
    Stefano, Turchini
    ;
    Daniele, Catone
    ;
    Nicola, Zema
    ;
    Giorgio, Contini
    ;
    Tommaso, Prosperi
    ;
    DECLEVA, PIETRO
    ;
    STENER, MAURO
    ;
    Flaminia, Rondino
    ;
    Susanna, Piccirillo
    ;
    Kevin, C. Prince
    ;
    Maurizio, Speranza
    A study of (R)-3-methylcyclopentanone [(R)-3-MCP] by photoelectron spectroscopy and photoelectron circular dichroism (PECD) is presented. The synchrotron radiation gas-phase photoelectron spectra of (R)-3-MCP were measured and are discussed on the basis of different theoretical methodologies. The experimental dichroism of (R)-3-MCP for selected deconvoluted valence states and for the carbonyl carbon 1s core state are reported and reproduced well by calculated dispersions generated by considering the contributions of two different conformers. The theoretical dichroic parameters are calculated by employing a multicentre basis set of B-spline functions and a Kohn–Sham Hamiltonian. Temperature-dependent PECD studies of the HOMO state and the carbonyl carbon 1s core level allowed the separation of the contributions of each conformer by photoelectron dichroism. This new approach clearly shows how the PECD methodology is sensitive to conformational and structural changes of unoriented (R)-3-MCP in the gas phase, opening up new perspectives in the characterisation of chiral molecular systems.
    WOS© Citazioni 34  1
  • Pubblicazione
    Fullerene derivatives: an actractive tool for biological application
    ( 2003)
    BOSI S
    ;
    DA ROS, TATIANA
    ;
    SPALLUTO, GIAMPIERO
    ;
    PRATO, MAURIZIO
    The fullerene family, and especially C60, has very appealing photo-, electro-chemical and physical properties, which can be exploited in many and different biological fields. Fullerene is able to fit inside the hydrophobic cavity of HIV proteases, inhibiting the access of substrates to the catalytic site of the enzyme. It can be used as radical scavenger; in fact some water-soluble derivatives are able to reduce ROS concentrations. At the same time, if exposed to light, fullerene can produce singlet oxygen in high quantum yields. This action, together with the direct electron transfer from excited state of fullerene and DNA bases, can be used to cleave DNA. In this review we report the most recent aspects of fullerene biological applications.
      2
  • Pubblicazione
    Chemical, biological and antitumor properties of ruthenium-dimethylsulfoxide complexes
    (Springer-Verlag, 1989)
    G. MESTRONI
    ;
    ALESSIO, ENZO
    ;
    M. CALLIGARIS
    ;
    W. M. ATTIA
    ;
    F. QUADRIFOGLIO
    ;
    S. CAUCI
    ;
    SAVA, GIANNI
    ;
    ZORZET, SONIA
    ;
    PACOR, SABRINA
    ;
    C. MONTI BRAGADIN
    ;
    M. TAMARO
    ;
    DOLZANI, LUCILLA
      1
  • Pubblicazione
    EAFGAS off-gas gas analysis system:
    ( 2017)
    Jan Kaspar
    ;
    Ilan Boscarato
    To be completed after deposition of patent application
      2
  • Pubblicazione
      1
  • Pubblicazione
    Large scale applications of immobilized enzymes call for sustainable and inexpensive solutions: rice husks as renewable alternatives to fossil-based organic resins
    ( 2016)
    Corici, Livia
    ;
    FERRARIO, VALERIO
    ;
    Pellis, Alessandro
    ;
    EBERT, CYNTHIA
    ;
    Lotteria, Simone
    ;
    CANTONE, SARA
    ;
    VOINOVICH, DARIO
    ;
    GARDOSSI, Lucia
    Despite the extensive efforts of the scientific community towards the development of a vast variety of immobilization methods, there is a limited number of immobilized biocatalysts used at an industrial scale. Most often, cost issues prevent the transfer of methodologies to large scale but more recently sustainability criteria are also becoming increasingly relevant, so that petroleum based carriers for enzyme immobilization appear unsuitable for responding to the new challenges of green and renewable chemistry. Here we report, for the first time, a preliminary overview of the potential of rice husks as carriers to be employed for both physical and covalent immobilization of enzymes. The data indicate that the chemical versatility of this lignocellulosic biomass, containing also silica, opens wide scenarios for optimizing different immobilization procedures requiring minimal pre-treatments and applicable to various enzymes and process conditions. The mechanical and chemical robustness of rice husks, along with their virtually unlimited availability worldwide, make this inexpensive natural matrix a promising candidate for replacing organic fossil-based carriers for enzyme immobilization.
    WOS© Citazioni 32
  • Pubblicazione
    Photoionization Dynamics of the Tetraoxo Complexes OsO4 and RuO4
    ( 2020)
    Schio L.
    ;
    Alagia M.
    ;
    Toffoli D.
    ;
    Decleva P.
    ;
    Richter R.
    ;
    Schalk O.
    ;
    Thomas R. D.
    ;
    Mucke M.
    ;
    Salvador F.
    ;
    Bertoch P.
    ;
    Benedetti D.
    ;
    Dri C.
    ;
    Cautero G.
    ;
    Sergo R.
    ;
    Stebel L.
    ;
    Vivoda D.
    ;
    Stranges S.
    The photoionization dynamics of OsO4 and RuO4, chosen as model systems of small-size mononuclear heavy-metal complexes, has been theoretically studied by the time-dependent density functional theory (TDDFT). Accurate experimental measurements of photoionization dynamics as a benchmarking test for the theory are reported for the photoelectron asymmetry parameters of outer valence ionizations of OsO4, measured in the 17-90 eV photon energy range. The theoretical results are in good agreement with the available experimental data. The observed dynamical behavior of partial cross sections and asymmetry parameters has been related to both the coupling to the continuum of discrete excited states, giving strong modulations in the photon energy dependency, and the atomic composition of the initial ionized states, which determines the rate of decay of ionization probability for increasing excitation energies. Overall, an extensive analysis of the photoionization dynamics for valence and core orbitals is presented, showing good agreement with all the available experimental data. This provides confidence for the validity of the TDDFT approach in describing photoionization of heavy transition element compounds, with the perspective of being used for larger systems. Further experimental work is suggested for RuO4 to gather evidence of the sensitivity of the theoretical method to the nature of the metal atom.
    WOS© Citazioni 2
  • Pubblicazione
    DOUBLE FUNCTIONALISATION OF CARBON NANOTUBES FOR MULTIMODAL DRUG DELIVERY
    ( 2006)
    G. PASTORIN
    ;
    W. WU
    ;
    S. WIECKOWSKI
    ;
    J. P. BRIAND
    ;
    K. KOSTARELOS
    ;
    PRATO, MAURIZIO
    ;
    A. BIANCO
      1
  • Pubblicazione
    Electrochemical growth of platinum nanostructures for enhanced ethanol oxidation
    ( 2015)
    WANG, LIANQIN
    ;
    M. Bevilacqua
    ;
    J. Filippi
    ;
    FORNASIERO, Paolo
    ;
    M. Innocenti
    ;
    A. Lavacchi
    ;
    A. Marchionni
    ;
    H. A. Miller
    ;
    F. Vizza
    The catalytic activation of polycrystalline platinum toward ethanol electro-oxidation in alkaline environment has been obtained by a square wave potential treatment.A detailed analysis that explores the effect of the period of the square wave on the evolution of the catalytic properties of the Pt surface is reported. The catalytic behavior of the treated and untreated surfaces has been interpreted both in terms of real surface area and surface structure evolution.The most active surface has been produced with a treating period time of 120. min. Interestingly the maximum stability has been obtained with the sample produced with square wave potential with a period of 360. min with slightly lower initial performance.We have also found that the treated samples limit C. C cleavage, as compared to bare Pt, offering an effective strategy to minimize the formation of CO. Via in situ FTIR we have demonstrated that the major oxidation product is acetate. These findings are especially important in view of the application of Pt as a catalyst in alkaline direct ethanol fuel cells.
    WOS© Citazioni 15  3
  • Pubblicazione
    Customizing the Electrochemical Properties of Carbon Nanodots by Using Quinones in Bottom-Up Synthesis
    ( 2018)
    Rigodanza F.
    ;
    Dordevic L.
    ;
    Arcudi F.
    ;
    Prato M.
    We show how the redox potentials of carbon nanodots (CNDs) can be modulated by employing quinones as electroactive precursors during a microwave-assisted synthesis. We prepared and characterized a redox library of CNDs, demonstrating that this approach can promote the use of carbon nanodots for ad hoc applications, including photocatalysis.
    WOS© Citazioni 59