Ora in mostra 1 - 10 di 2356
  • Pubblicazione
    Searching for SARS-COV-2 on particulate matter: A possible early indicator of COVID-19 epidemic recurrence
    ( 2020)
    Setti L.
    ;
    Passarini F.
    ;
    De Gennaro G.
    ;
    ; ;
    Ruscio M.
    ;
    Piscitelli P.
    ;
    Colao A.
    ;
    Miani A.
    A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However, in many countries a “Phase-2” is approaching and many activities will re-open soon, although with some differences depending on the severity of the outbreak experienced and SARS-COV-2 estimated diffusion in the general population. At the present, possible relapses of the epidemic cannot be excluded until effective vaccines or immunoprophylaxis with human recombinant antibodies will be properly set up and commercialized. COVD-19-related quarantines have triggered serious social challenges, so that decision makers are concerned about the risk of wasting all the sacrifices imposed to the people in these months of quarantine. The availability of possible early predictive indicators of future epidemic relapses would be very useful for public health purposes, and could potentially prevent the suspension of entire national economic systems. On 16 March, a Position Paper launched by the Italian Society of Environmental Medicine (SIMA) hypothesized for the first time a possible link between the dramatic impact of COVID-19 outbreak in Northern Italy and the high concentrations of particulate matter (PM10 and PM2.5) that characterize this area, along with its well-known specific climatic conditions. Thereafter, a survey carried out in the U.S. by the Harvard School of Public Health suggested a strong association between increases in particulate matter concentration and mortality rates due to COVID-19. The presence of SARS-COV-2 RNA on the particulate matter of Bergamo, which is not far from Milan and represents the epicenter of the Italian epidemic, seems to confirm (at least in case of atmospheric stability and high PM concentrations, as it usually occurs in Northern Italy) that the virus can create clusters with the particles and be carried and detected on PM10 . Although no assumptions can be made concerning the link between this first experimental finding and COVID-19 outbreak progression or severity, the presence of SARS-COV-2 RNA on PM10 of outdoor air samples in any city of the world could represent a potential early indicator of COVID-19 diffusion. Searching for the viral genome on particulate matter could therefore be explored among the possible strategies for adopting all the necessary preventive measures before future epidemics start.
    WOS© Citazioni 85
  • Pubblicazione
    Synthesis of chiral, enantiopure allylic amines by the Julia olefination of α-amino esters
    ( 2016) ; ;
    FANFONI, LIDIA
    ;
    GARBO, MICHELE
    ;
    REGINI, GIORGIA
    ;
    The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of α-amino aldehydes.
    Scopus© Citazioni 2WOS© Citazioni 3
  • Pubblicazione
    Fate of the antimetastatic ruthenium complex ImH[trans-RuCl4(DMSO)Im] after acute i.v. treatment in mice
    ( 2000)
    Cocchietto M.
    ;
    Salerno G.
    ;
    ;
    Mestroni G.
    ;
    SAVA, GIANNI
    ANTICANCER RES.
  • Pubblicazione
    The qualità of virgin olive oils with reference to the Istria productions
    (Istrian liquid green gold, 2002)
    A. CICHELLI
    ;
    L. LIBERATORE
    ;
    ;
    L. GABRIELLI FAVRETTO
    ;
    I. ZUZIC
      1
  • Pubblicazione
    Chapter 1: A3 adenosine receptor ligands in the treatment of inflammation and cancer
    (Nova Publishers, 2016)
    Cheong, Siew Lee
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    ;
    Tan Bon Wu, Aaron
    ;
    ;
    Pastorin, Giorgia
    A3 adenosine receptor is a G protein-coupled receptor belonging to P1 family of purinergic receptors. It is widely distributed in human organs and tissues with various expression levels. In particular, A3 adenosine receptor is highly expressed in several immune cells and cancer cell lines. For this reason its modulation is intensively studied for the involvement in inflammation and cancer. Ligands (agonists and antagonists) presenting high affinity and selectivity for the A3 adenosine receptor are essential for determining the role of such receptor in these pathophysiological conditions and, eventually, for the development of potential drugs for their treatment. In this review we summarize old and new discoveries on therapeutic applications of the A3 adenosine receptor in inflammation and cancer, and highlight the most important agonists and antagonists developed for the A3 adenosine receptor, explicitlythose in clinical trials for the treatment of inflammation and/or cancer.
  • Pubblicazione
    Formation and Structure of a Cobalt(III) Complex Containing a Nonstabilized Pyridinium Ylide Ligand
    ( 2014)
    SIEGA, PATRIZIA
    ;
    DREOS, RENATA
    ;
    BRANCATELLI, GIOVANNA
    ;
    DEMITRI, NICOLA
    ;
    The reaction of [CoIII(4,4′dmsalen)(CH2Cl)(S)], where 4,4′dmsalen = 4,4′-dimethylsalen and S = solvent, with pyridine led to the formation of [CoIII(4,4′dmsalen)(CH2py)(Cl)], containing a nonstabilized pyridinium ylide as axial ligand. The complex has been unambiguously characterized by single-crystal X-ray diffraction analysis. Time-resolved 1H NMR spectra showed that the formation of [CoIII(4,4′dmsalen)(CH2py)(Cl)] occurs in a two-step process involving a metallacyclized intermediate, cis-β-[CoIII(4,4′dmsalenCH2)(py)(S)]+. A similar experiment carried out in the presence of different nitrogen bases having higher pKa values (4-Me-py or 4-t-Bu-py) allowed a better separation of the two consecutive reactions. The almost complete conversion of [CoIII(4,4′dmsalen)(CH2Cl)(S)] in the cyclized intermediate before the formation of the ylide indicates that the ylide complex forms exclusively through the nucleophilic attack of the nitrogen base at the −CH2O– carbon of the cyclized species, whereas a parallel direct conversion through the displacement of Cl– from the axial CH2Cl group of [CoIII(4,4′dmsalen)(CH2Cl)(S)] may be ruled out.
    WOS© Citazioni 3
  • Pubblicazione
    Scopus© Citazioni 36WOS© Citazioni 36