Dipartimento di Scienze Chimiche e Farmaceutiche (UniTS)
Immagine di anteprima
Direttore
Data di fondazione
2012
Sito Web
Descrizione
Il Dipartimento di Scienze Chimiche e Farmaceutiche (DSCF) dell’Università degli Studi di Trieste nasce nel 2010 dall’unione dei pre-esistenti Dipartimenti di Scienze Chimiche e di Scienze Farmaceutiche e dall’autunno 2012 svolge le funzioni didattiche delle ex-Facoltà di Scienze MMFFNN e di Farmacia relative ai corsi di laurea Triennale e Magistrale in Chimica e ai corsi a ciclo unico in Farmacia e in Chimica e Tecnologia Farmaceutiche. Il DSCF gestisce la Scuola di Dottorato in Scienze e Tecnologie Chimiche e farmaceutiche e partecipa alla scuola di Dottorato in Nanotecnologie dell’Università di Trieste. Il DSCF ospita un’importante biblioteca di chimica, numerosi laboratori didattici e di ricerca, assieme a strumentazioni e facilities dedicati alla ricerca di base ed applicata nelle varie discipline chimiche. L’attività di ricerca si articola in diversi ambiti che vanno dalla Progettazione, sintesi e formulazione di farmaci, alla Chimica supramolecolare e nanotecnologie, alla Sintesi e struttura di biomolecole, alla Chimica sostenibile e ambientale e alla Chimica teorica e computazionale, promuovendo attività di ricerca scientifica d’avanguardia con contatti scientifici a livello nazionale ed internazionale. Il Dipartimento si propone nei confronti del mondo esterno (industrie, enti di ricerca pubblici e privati, ecc.) come punto di riferimento culturale e di supporto per la ricerca chimica.
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Ora in mostra 1 - 10 di 4145
  • Pubblicazione
    Conformational Sensitivity in Photoelectron Circular Dichroism of 3-Methylcyclopentanone
    ( 2013)
    Stefano, Turchini
    ;
    Daniele, Catone
    ;
    Nicola, Zema
    ;
    Giorgio, Contini
    ;
    Tommaso, Prosperi
    ;
    DECLEVA, PIETRO
    ;
    STENER, MAURO
    ;
    Flaminia, Rondino
    ;
    Susanna, Piccirillo
    ;
    Kevin, C. Prince
    ;
    Maurizio, Speranza
    A study of (R)-3-methylcyclopentanone [(R)-3-MCP] by photoelectron spectroscopy and photoelectron circular dichroism (PECD) is presented. The synchrotron radiation gas-phase photoelectron spectra of (R)-3-MCP were measured and are discussed on the basis of different theoretical methodologies. The experimental dichroism of (R)-3-MCP for selected deconvoluted valence states and for the carbonyl carbon 1s core state are reported and reproduced well by calculated dispersions generated by considering the contributions of two different conformers. The theoretical dichroic parameters are calculated by employing a multicentre basis set of B-spline functions and a Kohn–Sham Hamiltonian. Temperature-dependent PECD studies of the HOMO state and the carbonyl carbon 1s core level allowed the separation of the contributions of each conformer by photoelectron dichroism. This new approach clearly shows how the PECD methodology is sensitive to conformational and structural changes of unoriented (R)-3-MCP in the gas phase, opening up new perspectives in the characterisation of chiral molecular systems.
    WOS© Citazioni 34  1
  • Pubblicazione
    Chemical, biological and antitumor properties of ruthenium-dimethylsulfoxide complexes
    (Springer-Verlag, 1989)
    G. MESTRONI
    ;
    ALESSIO, ENZO
    ;
    M. CALLIGARIS
    ;
    W. M. ATTIA
    ;
    F. QUADRIFOGLIO
    ;
    S. CAUCI
    ;
    SAVA, GIANNI
    ;
    ZORZET, SONIA
    ;
    PACOR, SABRINA
    ;
    C. MONTI BRAGADIN
    ;
    M. TAMARO
    ;
    DOLZANI, LUCILLA
      1
  • Pubblicazione
    EAFGAS off-gas gas analysis system:
    ( 2017)
    Jan Kaspar
    ;
    Ilan Boscarato
    To be completed after deposition of patent application
      2
  • Pubblicazione
    Large scale applications of immobilized enzymes call for sustainable and inexpensive solutions: rice husks as renewable alternatives to fossil-based organic resins
    ( 2016)
    Corici, Livia
    ;
    FERRARIO, VALERIO
    ;
    Pellis, Alessandro
    ;
    EBERT, CYNTHIA
    ;
    Lotteria, Simone
    ;
    CANTONE, SARA
    ;
    VOINOVICH, DARIO
    ;
    GARDOSSI, Lucia
    Despite the extensive efforts of the scientific community towards the development of a vast variety of immobilization methods, there is a limited number of immobilized biocatalysts used at an industrial scale. Most often, cost issues prevent the transfer of methodologies to large scale but more recently sustainability criteria are also becoming increasingly relevant, so that petroleum based carriers for enzyme immobilization appear unsuitable for responding to the new challenges of green and renewable chemistry. Here we report, for the first time, a preliminary overview of the potential of rice husks as carriers to be employed for both physical and covalent immobilization of enzymes. The data indicate that the chemical versatility of this lignocellulosic biomass, containing also silica, opens wide scenarios for optimizing different immobilization procedures requiring minimal pre-treatments and applicable to various enzymes and process conditions. The mechanical and chemical robustness of rice husks, along with their virtually unlimited availability worldwide, make this inexpensive natural matrix a promising candidate for replacing organic fossil-based carriers for enzyme immobilization.
    WOS© Citazioni 32
  • Pubblicazione
    Photoionization Dynamics of the Tetraoxo Complexes OsO4 and RuO4
    ( 2020)
    Schio L.
    ;
    Alagia M.
    ;
    Toffoli D.
    ;
    Decleva P.
    ;
    Richter R.
    ;
    Schalk O.
    ;
    Thomas R. D.
    ;
    Mucke M.
    ;
    Salvador F.
    ;
    Bertoch P.
    ;
    Benedetti D.
    ;
    Dri C.
    ;
    Cautero G.
    ;
    Sergo R.
    ;
    Stebel L.
    ;
    Vivoda D.
    ;
    Stranges S.
    The photoionization dynamics of OsO4 and RuO4, chosen as model systems of small-size mononuclear heavy-metal complexes, has been theoretically studied by the time-dependent density functional theory (TDDFT). Accurate experimental measurements of photoionization dynamics as a benchmarking test for the theory are reported for the photoelectron asymmetry parameters of outer valence ionizations of OsO4, measured in the 17-90 eV photon energy range. The theoretical results are in good agreement with the available experimental data. The observed dynamical behavior of partial cross sections and asymmetry parameters has been related to both the coupling to the continuum of discrete excited states, giving strong modulations in the photon energy dependency, and the atomic composition of the initial ionized states, which determines the rate of decay of ionization probability for increasing excitation energies. Overall, an extensive analysis of the photoionization dynamics for valence and core orbitals is presented, showing good agreement with all the available experimental data. This provides confidence for the validity of the TDDFT approach in describing photoionization of heavy transition element compounds, with the perspective of being used for larger systems. Further experimental work is suggested for RuO4 to gather evidence of the sensitivity of the theoretical method to the nature of the metal atom.
    WOS© Citazioni 2
  • Pubblicazione
    Customizing the Electrochemical Properties of Carbon Nanodots by Using Quinones in Bottom-Up Synthesis
    ( 2018)
    Rigodanza F.
    ;
    Dordevic L.
    ;
    Arcudi F.
    ;
    Prato M.
    We show how the redox potentials of carbon nanodots (CNDs) can be modulated by employing quinones as electroactive precursors during a microwave-assisted synthesis. We prepared and characterized a redox library of CNDs, demonstrating that this approach can promote the use of carbon nanodots for ad hoc applications, including photocatalysis.
    WOS© Citazioni 59
  • Pubblicazione
    Preparation and in vitro/in vivo characterisation of a melt pelletised paracetamol/stearic acid sustained release delivery system
    ( 2004)
    Grassi M.
    ;
    Voinovich D.
    ;
    Grabnar I.
    ;
    FRANCESCHINIS, Elena
    ;
    Perissutti B.
    ;
    Filipovic-Grcic J.
    The potential of a sustained release formulation for paracetamol produced by melt pelletisation was investigated. After the production of the pellets, based on the combination of stearic acid as a melting binder and anhydrous lactose as a filler, the 3000–2000 μm size fraction was selected in the light of the promising in vitro dissolution results for further characterisations, including scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), specific surface area and true density determination. Hence the release mechanism was analysed with the help of an appropriate mathematical model. The mathematical model was built on the hypotheses that drug diffusion and solid drug dissolution in the release environment are the key phenomena affecting drug release kinetics. Bioavailability of the developed formulation was evaluated in an in vivo study in eight subjects
    WOS© Citazioni 2
  • Pubblicazione
    Pattern recognition and anomaly detection by self-organizing maps in a multi month e-nose survey at an industrial site
    ( 2020)
    Licen S.
    ;
    Di Gilio A.
    ;
    Palmisani J.
    ;
    Petraccone S.
    ;
    de Gennaro G.
    ;
    Barbieri P.
    Currently people are aware of the risk related to pollution exposure. Thus odor annoyances are considered a warning about the possible presence of toxic volatile compounds. Malodor often generates immediate alarm among citizens, and electronic noses are convenient instruments to detect mixture of odorant compounds with high monitoring frequency. In this paper we present a study on pattern recognition on ambient air composition in proximity of a gas and oil pretreatment plant by elaboration of data from an electronic nose implementing 10 metal-oxide-semiconductor (MOS) sensors and positioned outdoor continuously during three months. A total of 80,017 e-nose vectors have been elaborated applying the self-organizing map (SOM) algorithm and then k-means clustering on SOM outputs on the whole data set evidencing an anomalous data cluster. Retaining data characterized by dynamic responses of the multisensory system, a SOM with 264 recurrent sensor responses to air mixture sampled at the site and four main air type profiles (clusters) have been identified. One of this sensor profiles has been related to the odor fugitive emissions of the plant, by using ancillary data from a total volatile organic compound (VOC) detector and wind speed and direction data. The overall and daily cluster frequencies have been evaluated, allowing us to identify the daily duration of presence at the monitoring site of air related to industrial emissions. The refined model allowed us to confirm the anomaly detection of the sensor responses.
    WOS© Citazioni 13
  • Pubblicazione
    Covalent Carbon Nanotube Functionalization
    (Springer, 2015)
    SYRGIANNIS, ZOIS
    ;
    MELCHIONNA, MICHELE
    ;
    PRATO, MAURIZIO
    Covalent functionalization of carbon nanotubes (CNTs) is the attachment of chemical moieties to the CNT tubular structure via the formation of covalent bonds, which share at least one pair of electrons between the CNT and the introduced chemical moiety. The typical scope of covalent sidewall functionalization is to increase not only the dispersibility and processability of CNTs but often also their reactivity. As a result, CNT physicochemical properties can be fine-tuned for intended applications, thus opening the way to the assembly of functional advanced materials, including nanotube-based composites or hybrids.
  • Pubblicazione
    Diverse Applications of Nanomedicine
    ( 2017)
    Pelaz, Beatriz
    ;
    Alexiou, Christoph
    ;
    Alvarez Puebla, Ramon A.
    ;
    Alves, Frauke
    ;
    Andrews, Anne M.
    ;
    Ashraf, Sumaira
    ;
    Balogh, Lajos P.
    ;
    BALLERINI, Laura
    ;
    Bestetti, Alessandra
    ;
    Brendel, Cornelia
    ;
    BOSI, Susanna
    ;
    Carril, Monica
    ;
    Chan, Warren C. W.
    ;
    Chen, Chunying
    ;
    Chen, Xiaodong
    ;
    Chen, Xiaoyuan
    ;
    Cheng, Zhen
    ;
    Cui, Daxiang
    ;
    Du, Jianzhong
    ;
    Dullin, Christian
    ;
    Escudero, Alberto
    ;
    Feliu, Neus
    ;
    Gao, Mingyuan
    ;
    George, Michael
    ;
    Gogotsi, Yury
    ;
    Grünweller, Arnold
    ;
    Gu, Zhongwei
    ;
    Halas, Naomi J.
    ;
    Hampp, Norbert
    ;
    Hartmann, Roland K.
    ;
    Hersam, Mark C.
    ;
    Hunziker, Patrick
    ;
    Jian, Ji
    ;
    Jiang, Xingyu
    ;
    Jungebluth, Philipp
    ;
    Kadhiresan, Pranav
    ;
    Kataoka, Kazunori
    ;
    Khademhosseini, Ali
    ;
    Kopeček, Jindřich
    ;
    Kotov, Nicholas A.
    ;
    Krug, Harald F.
    ;
    Lee, Dong Soo
    ;
    Lehr, Claus Michael
    ;
    Leong, Kam W.
    ;
    Liang, Xing Jie
    ;
    Ling Lim, Mei
    ;
    Liz Marzán, Luis M.
    ;
    Ma, Xiaowei
    ;
    Macchiarini, Paolo
    ;
    Meng, Huan
    ;
    Möhwald, Helmuth
    ;
    Mulvaney, Paul
    ;
    Nel, Andre E.
    ;
    Nie, Shuming
    ;
    Nordlander, Peter
    ;
    Okano, Teruo
    ;
    Oliveira, Jose
    ;
    Park, Tai Hyun
    ;
    Penner, Reginald M.
    ;
    PRATO, MAURIZIO
    ;
    Puntes, Victor
    ;
    Rotello, Vincent M.
    ;
    Samarakoon, Amila
    ;
    Schaak, Raymond E.
    ;
    Shen, Youqing
    ;
    Sjöqvist, Sebastian
    ;
    Skirtach, Andre G.
    ;
    Soliman, Mahmoud G.
    ;
    Stevens, Molly M.
    ;
    Sung, Hsing Wen
    ;
    Tang, Ben Zhong
    ;
    Tietze, Rainer
    ;
    Udugama, Buddhisha N.
    ;
    Vanepps, J. Scott
    ;
    Weil, Tanja
    ;
    Weiss, Paul S.
    ;
    Willner, Itamar
    ;
    Wu, Yuzhou
    ;
    Yang, Lily
    ;
    Yue, Zhao
    ;
    Zhang, Qian
    ;
    Zhang, Qiang
    ;
    Zhang, Xian En
    ;
    Zhao, Yuliang
    ;
    Zhou, Xin
    ;
    Parak, Wolfgang J.
    The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.
    Scopus© Citazioni 680WOS© Citazioni 858