Concrete is the most used building material in the world: its fundamental component is clinker, which, only for the production process, represents 5-7% of the global CO2 emissions (Coppola, 2019). Therefore, it is advantageous to replace the use of concrete with other more sustainable materials, as wood. From the point of view of the CO2 emissions, wood not only has a limited release in the production phase, but even, in a balance that also considers the development phase of the tree, it appears to absorb rather than emit carbon dioxide. The objective of this study is therefore to compare, in terms of CO2 emissions, the same building built in concrete rather than wood. The entire life cycle of structural materials is taken into consideration (production, transport, construction and finally deconstruction and disposal phases at the end of their life): the method used is the LCA analysis.