Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata
Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory
activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using
the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17,
19, 20) revealed an effect comparable (ID50 = 0.18 0.72 lmol/cm2) to that of the reference drug indomethacin
(ID50 = 0.23 lmol/cm2), a non-steroidal anti-inflammatory drug.
