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Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase

CATENI, FRANCESCA
•
P. BONIVENTO
•
PROCIDA, GIUSEPPE
altro
E. BANFI
2007
  • journal article

Periodico
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract
Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains.
DOI
10.1016/J.BMCL.2007.01.019
WOS
WOS:000245827900029
SCOPUS
2-s2.0-33847650096
Archivio
http://hdl.handle.net/11368/1698650
Diritti
metadata only access
Soggetti
  • Chemoenzymatic synthe...

  • Monoglycosyl diglycer...

  • Pancreatic lipase

  • Antimicrobial activit...

Web of Science© citazioni
14
Data di acquisizione
Jun 16, 2022
Visualizzazioni
2
Data di acquisizione
Jun 8, 2022
Vedi dettagli
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