Pubblicazione:
Discovery platforms for RNA therapeutics
Discovery platforms for RNA therapeutics
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Data
2024
Autori
Ciucci, Giulio
Braga, Luca
Zacchigna, Serena
Titolo del Periodico
ISSN Periodico
Titolo volume
Editore
Progetti di ricerca
Strutture
Fascicolo Periodico
Abstract
: RNA therapeutics are emerging as a unique opportunity to drug currently "undruggable" molecules and diseases. While their advantages over conventional, small molecule drugs, their therapeutic implications and the tools for their effective in vivo delivery have been extensively reviewed, little attention has been so far paid to the technological platforms exploited for the discovery of RNA therapeutics. Here, we provide an overview of the existing platforms and ex vivo assays for RNA discovery, their advantages and disadvantages, as well as their main fields of application, with specific focus on RNA therapies that have reached either phase 3 or market approval.
Descrizione
Parole chiavi
RNA therapeutic,
drug discovery,
functional screening