The paper proposes a semiotic framework inspired to the
Generative Trajectory of Meaning by A.J. Greimas to the design
and analysis of hypermedia. The framework is structured into four
levels of signification and allows the designer to control the
semantic coherence and optimize the communication during the
hypermedia development. We investigate its practical feasibility
by constructing an instructional hypermedia regarding a collection
of ancient mosaics from a roman villa. Our results indicate that
the proposed approach opens novel perspectives, and looks
promising towards the definition of semiotic methodologies of
hypermedia design.