The dysregulated inflammation and coagulation observed in COVID-19 is similar to that of multifactorial medical ARDS, where ample evidence has demonstrated the ability of prolonged corticosteroids to down-regulate inflammation-coagulation-fibroproliferation and accelerate disease resolution. Additionally, the CT findings of ground-glass opacities and the histological findings of hyaline membrane and inflammatory exudates are compatible with corticosteroid-responsive inflammatory lung disease. A recent study showed that COVID-19 is associated with a cytokine elevation profile that is reminiscent of secondary hemophagocytic lymphohistiocytosis, a condition responsive to corticosteroids.
