The unbalanced production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
has been implicated in the pathogenesis of several human diseases. Indeed, there is great interest in developing
methods for measuring quantitatively and selectively the production of ROS/RNS in living cells. Here, we report
a simple and sensitive method for the detection of ROS, based on surface-enhanced Raman scattering (SERS)
spectroscopy.