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An Unprecedented Catalytic Motif Revealed in The Model Structure of Amide Hydrolyzing Antibody 312D6.

BENEDETTI, FABIO
•
BERTI, FEDERICO
•
BRADY K.
altro
THOMAS N. R.
2004
  • journal article

Periodico
CHEMBIOCHEM
Abstract
Here we report the results of a docking analysis carried out on the homology model of the variable fragment (Fv) region of antibody 312d6. A novel catalytic motif based on an arginine dyad, unprecedented in antibody hydrolases, is identified by this study.
DOI
10.1002/cbic.200300738
WOS
WOS:000189182600017
Archivio
http://hdl.handle.net/11368/1690089
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0034645711
Diritti
metadata only access
Soggetti
  • catalytic antibody

  • homology modeling

  • sulfone

  • amide hydrolysi

  • transition state mode...

Web of Science© citazioni
5
Data di acquisizione
Mar 20, 2024
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