Bone is a complex tissue that have many function, when bone remodeling becomes perturbed
we can assist at many pathologies. The key factor in these pathologies is a perturbation of RANKL/RANK/OPG
pathways. We have tune up a 3D culture system that have the advantage to produce osteoclast cells more
physiological than the administration of the recombinant RANKL protein. This can be useful when study new
drugs to avoid the cross-reaction with the exogenous cytokines.
