In this paper, we discuss the foucaultian and agambenian concepts of biopolitics. This comparison between Foucault and Agamben is divided in three parts. First of all, we show how ontologistic and anti-historical nuances of Agamben’s concept of biopolitics don’t allow to grasp both the socio-economic contradictions and the positive aspects of biopolitics. In this section we reflect also on the theoretical aporia of Agamben’s interpretation of Aristotelian bios. In the second place, we show the agambenian misunderstanding of the relationship between subject and self in the last Foucault. In the end, we compare the foucaultian and agambenian concepts of public health.