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Non-Fickian diffusion enhanced by temperature

Ferreira, José A.
•
Grassi, Mario
•
Gudiño, Elías
•
de Oliveira, Paula
2025
  • journal article

Periodico
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS
Abstract
In this paper we present a novel mathematical model to describe the permeation of a fluid through a polymeric matrix, loaded with drug molecules, followed by its subsequent desorption. Both phenomena are enhanced by temperature. We deduce energy estimates and stability estimates for the weak solution of the model, showing that this solution of the problem is stable in bounded time intervals. Numerical simulations illustrate how the coupling effects, of viscoelastic properties and thermal external assistance, can have a central role in the design of drug delivery devices.
DOI
10.1016/j.cam.2024.116314
WOS
WOS:001339352800001
Archivio
https://hdl.handle.net/11368/3113754
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85206480794
https://www.sciencedirect.com/science/article/pii/S0377042724005624?via=ihub
Diritti
closed access
license:copyright editore
license uri:iris.pri02
FVG url
https://arts.units.it/request-item?handle=11368/3113754
Soggetti
  • Drug delivery

  • Non-Fickian diffusion...

  • Thermosensitive polym...

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