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Successful treatment and FDG-PET/CT monitoring of HHV-6 encephalitis in a non-neutropenic patient: case report and literature review

Elda Righi
•
Alessia Carnelutti
•
Daniele Muser
altro
Matteo Bassetti
2017
  • journal article

Periodico
JOURNAL OF NEUROVIROLOGY
Abstract
Human herpesvirus (HHV)-6 reactivation is associated with severe forms of encephalitis among patients undergoing hematopoietic stem cell transplantation. Cases in non-neutropenic patients are uncommon. The efficacy of ganciclovir and other compounds that are used for the treatment of HHV-6 encephalitis remains suboptimal and linked to toxicity. Valganciclovir, the oral prodrug of ganciclovir, could be practical to treat outpatients, but it is not commonly used for severe cases. We report a case of HHV-6 encephalitis in a non-neutropenic patient successfully treated with valganciclovir and undergoing therapeutic drug monitoring in plasma and in the cerebrospinal fluid. Resolution of infectious foci was documented by cerebral MRI and F18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). A review of the literature on HHV-6 encephalitis is also reported.
DOI
10.1007/s13365-017-0566-4
WOS
WOS:000417742100011
Archivio
http://hdl.handle.net/11368/2955663
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85027860102
https://link.springer.com/article/10.1007/s13365-017-0566-4
Diritti
closed access
license:copyright editore
license:copyright editore
license:copyright editore
FVG url
https://arts.units.it/request-item?handle=11368/2955663
Soggetti
  • Cerebrospinal fluid d...

  • FDG-PET/CT

  • Hodgkin lymphoma

  • Human herpesvirus (HH...

  • Valganciclovir

  • Neurology

  • Neurology (clinical)

  • Cellular and Molecula...

  • Virology

Scopus© citazioni
5
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
6
La settimana scorsa
1
Data di acquisizione
Mar 21, 2024
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