Prostatic gland cryoablation (PGC) is a recently developed procedure for treatment of localized prostatic cancer. We report an unusual case of cancer regression following PGC, with retrograde colonization by a diffusely metastazing gastric adenocarcinoma. Thi case confirms that PGC is an important tool in the management of prostatic tumor and that it may be also considered in the tratment of locally invasive (pT3, C) disease.