Through the analysis of significant correspondences and a selected part of the editorial production, the essay aims to examine the collaborative relationships between the Theatine father Paolo Maria Paciaudi (1710-1785) and some men of letters and scholars who were at the same time scientists, or sometimes dealt with science. Formidable expert of erudite, literary, antiquarian and epigraphic studies, in the exercise of his institutional duties, developed between Turin, Genoa, Naples, Rome and finally Parma (where he arrived in 1762 on invitation of Duke Philip of Bourbon), Paciaudi himself did not disdain to deal with scientific topics and to favor the diffusion of modern science.