This paper reports an educational activity regarding the periodic table. This activity consists of a structured game path, known as an Escape room, in which first-year students of technical schools are divided into groups and asked to solve puzzle games, each related to the other, in order to lead them to a common aim. The importance of the various phases, including student involvement, debriefing and restitution, are discussed. The activity can be used both as consolidation of previous knowledge and as a catalyst for knowledge development in the discipline.