Logo del repository
  1. Home
 
Opzioni

Preparation and in vitro/in vivo characterisation of a melt pelletised paracetamol/stearic acid sustained release delivery system

Grassi M.
•
Voinovich D.
•
Grabnar I.
altro
Filipovic-Grcic J.
2004
  • journal article

Periodico
SPECTROSCOPY
Abstract
The potential of a sustained release formulation for paracetamol produced by melt pelletisation was investigated. After the production of the pellets, based on the combination of stearic acid as a melting binder and anhydrous lactose as a filler, the 3000–2000 μm size fraction was selected in the light of the promising in vitro dissolution results for further characterisations, including scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), specific surface area and true density determination. Hence the release mechanism was analysed with the help of an appropriate mathematical model. The mathematical model was built on the hypotheses that drug diffusion and solid drug dissolution in the release environment are the key phenomena affecting drug release kinetics. Bioavailability of the developed formulation was evaluated in an in vivo study in eight subjects
DOI
10.1155/2004/989502
WOS
WOS:000221869800028
SCOPUS
2-s2.0-2442657716
Archivio
http://hdl.handle.net/11368/2946769
http://www.hindawi.com/journals/spectroscopy/
Diritti
metadata only access
Soggetti
  • High shear mixer

  • In vitro dissolution

  • In vivo bioavailabili...

  • Melt pelletisation

  • Modelling of drug-rel...

  • Paracetamol

  • Sustained release

Web of Science© citazioni
2
Data di acquisizione
Mar 19, 2024
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback