This Research Topic collection entitled “Osteoporosis in Rheumatic Diseases, What’s New?”, compiled by authors from various countries, confirms that patients with rheumatic diseases are frequently also affected by osteoporosis (OP). All the articles included reported that OP is a major comorbidity in rheumatic patients due to factors like, chronic treatment, inflammation, immobility, low body mass index (BMI), and low vitamin D serum concentrations.