This paper is part of a reflection on the relationship between Henri Matisse’s pictorial work and the outline in contemporary architecture of a research characterized by overlaps and incursions, interferences and contaminations, that assumes the theme of phenomenology and refined relations between elements, the composition with the objects of reality, the work on the physical and conceptual margins of things, as essential questions able to condensing spatial values of great interest. Reinterpreting the painting lesson of Matisse, this paper reflects on the architectural interior space, on the edge as a habitable place, on the scale as a relational one, through an exploration on the contrary, a peripheral vision, able to sound out those (un)searchable interiors and depths that are together generators of space and functions of space.