The following issue of Esercizi Filosofici aims to provide some inputs for a re-discussion of philosophical naturalism. In particular, the issue focuses on naturalism as it has been expressed in modernity, from the Renaissance to the nineteenth century. The goal of this re-discussion is to broaden the semantics of naturalism, which to date has been exclusively referred to the sole “physicalist” meaning. Since the semantics of naturalism appears to be irretrievably linked to that of the term “nature”, such a re-discussion seems to open up new vistas in contemporary debate, creating room for thinking.