The research addresses the topic of intermodality in terms of technical, typological, and architectural response of infrastructure systems, considering their relationship with the territory and the landscape. The study starts from the hypothesis of the development of a comprehensive intermodal hub in the Ronchi dei Legionari Airport (Friuli-Venezia Giulia, Trieste, Italy), integrated with the network of local public transport and railway infrastructure, considered in a scenario of sustainability over the medium term and updated with respect to the current economic situation. The first phase of the research focused on the definition of the guidelines for the design of the intermodal hub. Subsequently, the study verified the hypothesis by modeling some alternative scenarios, whose results led to the identification of a highly comprehensive set of data, consistent with the financial framework. Lastly, urban verification: the identified scenarios constitute a framework of alternative options corresponding to the minimum, optimal and critical conditions of the system as a whole. The possible alternatives prove the degree of versatility of the proposed layout which provides, as a whole, the possibility of opting for one of the proposed scenarios or for a more complex combination of the proposed solutions.