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The African coelacanth genome provides insights into tetrapod evolution

Chris T. Amemiya
•
Jessica Alföldi
•
Alison P. Lee
altro
Kerstin Lindblad Toh
2013
  • journal article

Periodico
NATURE
Abstract
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.
DOI
10.1038/nature12027
WOS
WOS:000317599200027
Archivio
http://hdl.handle.net/11368/2682750
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84876271982
Diritti
metadata only access
Soggetti
  • adaptation, ancestry,...

Scopus© citazioni
476
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
507
Data di acquisizione
Mar 11, 2024
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