Palpable nodules on the penile shaft, called penile lumps, are encountered in benign conditions such as Peyronie disease and in malignant lesions such as squamous cell carcinoma. Malignant lesions of the penis account for less than 1% of all malignant cancers in the United States, and of these, approximately 95% are squamous cell carcinomas. The diagnostic approach is primarily clinical and depends on the patient’s medical history and the onset of the symptoms. Imaging examinations, including principally US and MRI, play a role in staging, preoperative planning, and assessing the vasculature and viability of the penile tissues. Because of the relative infrequency of penile diseases, performing and interpreting penile imaging studies can be challenging for radiologists with less experience in urogenital imaging
