Consensus of the Italian Primary Immunodeficiency Network on Transition Management from Pediatric to Adult Care in Patients Affected with Childhood Onset Inborn Errors of Immunity

Medical advances have dramatically improved the long-term prognosis of children and adolescents with Inborn Errors of Immunity (IEIs). Transfer of medical care of individuals with pediatric IEIs to adult facilities is a complex task also for the high number of distinct disorders, that requires involvement of patients and both pediatric and adult care providers. To date, there is no consensus on the optimal pathway of the transitional care process and no specific data are available in literature regarding patients with IEIs. We aimed to develop a consensus statement on the transition process to adult healthcare services for patients with IEIs. Physicians from major Italian Primary Immunodeficiency Network (IPINet) centers formulated and answered questions after examining the currently published literature on transition from childhood to adulthood. Authors voted on each recommendation. The most frequent IEIs, sharing common main clinical problems requiring full attention during the transitional phase, were categorized into different groups of Clinically Related Disorders (CRD). In each CRD, we focused on selected clinical issues representing the clinical hallmark during early adulthood.