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Hybridization approach to drug discovery inhibiting Mycobacterium tuberculosis. An overview

Zampieri, Daniele
•
Mamolo, Maria G
2021
  • journal article

Periodico
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Abstract
Tuberculosis is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent mainly due to Mycobacterium tuberculosis (MTB). Recently, clinical prognoses have worsened due to the emergence of multi-drug resistant (MDR) and extensive-drug resistant (XDR) tuberculosis which lead to the need of new, efficient and safely drugs. Among the several strategies, polypharmacology could be considered one of the best solutions, in particular the multi-target directed ligands strategy (MTDLs), based on the synthesis of hybrid ligands acting against two targets of the pathogen. The framework strategy comprises linking, fusing and merging approaches to develop new chemical entities. With these premises, this review aims to provide an overview of recent hybridization approach, in medicinal chemistry, of the most recent and promising multitargeting antimycobacterial candidates.
DOI
10.2174/1568026620666200819151342
WOS
WOS:000656142200002
Archivio
http://hdl.handle.net/11368/2977913
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107902152
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2977913
Soggetti
  • MDR

  • MIC

  • MTDL

  • antimycobacterial

  • cytotoxicity

  • hybridization

  • tuberculosis.

Scopus© citazioni
3
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
5
Data di acquisizione
Mar 16, 2024
Visualizzazioni
4
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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