A contribution to the epilithic and epiphytic lichen flora of Sardinia is presented. Seventy localities from both coastal and mountain area of western Sardinia have been investigated during four surveys from 2006 to 2008. In all, 390 taxa have been recorded. Three taxa are new to Italy (Allarthonia hypobela, Bacidia biatorina, Catillaria subviridis); 25 taxa are new to Sardinia. Pannaria rubiginosa and Melaspilea ochrohtalamia were re-collected after one century. Distribution and substrata are presented.