OBJECTIVE: The objective of the study was to examine mannose-binding
lectin gene (MBL2) polymorphisms in women with recurrent episodes
of bacterial vaginosis (BV).
STUDY DESIGN: Seventy-one women with at least 4 episodes of BV in
the last 12 months and 130 healthy controls were enrolled to evaluate
all 3 variant alleles of the MBL2 gene (polymorphisms at positions 52,
54, and 57 in the first exon of the MBL2 gene).
RESULTS: No statistically significant differences in MBL2 polymorphism
allelic and genotype frequencies were observed between women
with recurrent BV and controls. Allele A (wild type) was present, respectively,
in 78% of patients with recurrent BV and 77% of controls,
whereas the allele 0 was present in 22% of women with recurrent BV
and 23% of controls. MBL2 genotype and allelic frequencies were similar
in the 2 groups, and the 2 populations were in accordance with the
Hardy–Weiberg equilibrium.
CONCLUSION: Our results indicate that MBL2 gene polymorphisms do
not seem to be involved in susceptibility to recurrences of BV in gynecological
patients.
