In the last few years percutaneous cryoablation of the prostate has been reintroduced as an alternative means to prostatic carcinoma. Advantages of the technique include local effectiveness in eradicating tumors, minimal morbidity rate and lower costs when compared to radical surgery. We report a stydy documenting the histopathological changes seen in 317 biopsies obtained from 30 patients treated with cryosurgicsl ablation for prostate cancer.