In this work, a geomechanical study performed on a natural rock slope located in north-eastern Italy (Tagliamento River valley, Friuli Venezia Giulia Region) is presented. The detailed geomechanical survey has provided a large bulk of field data proving that the investigated limestone slope is characterized by strong rock mass damage, thus resulting in a critical stability condition. Field evidence includes: (1) local faults crossing the rock mass and representing internal sliding surfaces; (2) slickensides and fault slips within the rock mass; (3) fracture joints of gravity-induced origin; (4) strong rock mass damage in over-stressed zones of the slope; and (5) slope monitoring data recorded by some installed devices. Three failure scenarios have been identified: a wedge failure involving a limestone block of 110,000 m3 (failure scenario 1: BLOCK1); a larger wedge failure involving an assembled limestone block of 200,000 m3 (failure scenario 2: BLOCK1-2-3); and a retrogressive failure involving a rear dolomitic block possibly triggered by the collapse of the limestone slope, mobilizing a maximum volume of 335,000 m3 (failure scenario 3: DOLOMITIC BLOCK). This paper shows that to comprehensively study stability problems involving natural rock slopes we must consider the interaction between pre-existing discontinuities, internal sub-blocks subdividing the unstable slope, rock mass strength and gravity-induced fractures that form during the delicate phase preceding slope collapse. Gravity-induced joints can be differentiated on the field from those of tectonic origin on the basis of some geometrical features, in particular their lower persistence and higher joint roughness.