This monographic issue deals with the current relationship between the Humanities and artificial intelligence from an interdisciplinary point of view. The main objective of the various essays is, above all, to highlight the ethical, aesthetic, juridical, phenomenological, etc. challenges and problems produced by innovations in the field of artificial intelligence. The resulting general framework highlights, on the one hand, the modernization of atavistic issues of human beings and, on the other hand, a number of innovations fundamental to anthropological progress.