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1H and 10B NMR and MRI investigation of boron- and gadolinium–boron compounds in boron neutron capture therapy

M. Bonora
•
M. Corti
•
F. Borsa
altro
G. Vidari
2011
  • journal article

Periodico
APPLIED RADIATION AND ISOTOPES
Abstract
(10)B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include (1)H and (10)B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
DOI
10.1016/j.apradiso.2011.02.021
WOS
WOS:000297426000020
Archivio
http://hdl.handle.net/11368/2769401
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-80055074140
Diritti
metadata only access
Soggetti
  • BNCT

Scopus© citazioni
5
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Web of Science© citazioni
5
Data di acquisizione
Mar 28, 2024
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