Lyme disease is a tick-borne illness caused by Borrelia burgdorferi sensu lato and the nervous system involvement (e.g. meningitis, cranial neuropathies, radiculoneuritis, encephalitis) designates the Lyme disease (LNB) that may occur after infection as part of early disseminated Lyme disease (early LNB) or in untreated patients after at least 6 months (late LNB) after the infection. Herein we report a peculiar case of LNB as the patient, a 61-year-old man, developed meningoradiculoneuritis that relapsed after 9 months and to our knowledge very few cases of LNB relapse have been reported. Diagnosis of LNB was made, in both the episodes, according to EFNS criteria [1] on clinical and cerebrospinal and serum findings. We discussed whether the second episode of meningoradiculoneuritis was a relapse or a late LNB as well whether the second episode of meningoradiculoneuritis was due to a new infected tick bite occurred between the two episodes. Based on clinical and laboratory findings we believe that our patient developed a true relapse of LNB.
