We unveiled novel p65/RelA consensus sites in the promoter
of the beclin 1 gene and demonstrate that p65/RelA positively
modulates canonical autophagy in various human cell lines
both under basal conditions and upon induction by ceramide.
Interestingly, we find that T cell receptor-dependent activation
of Jurkat cells triggers an increase in the binding of p65/RelA
to the beclin 1 promoter accompanied by enhanced autophagy,
suggesting that p65/RelA could regulate T-cell activation and
homeostasis through autophagy.
