Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism.
As statins induce the translocation of cytosolic Bax to the
mitochondria and allow to permeabilize the mitochondrial
outer membrane during apoptosis, further studies will be
carried out on the expression of proapoptotic genes, such as
Bax or Bcl2.
These findings, even if obtained in an SH-SY5Y undifferentiated
cell line, surely represent a first step towards the
understanding of the neuronal damage caused by inflammation
processes in MA.
