Virtual Reality (VR) interfaces to e-commerce sites have recently begun to appear on the Internet, promising to make the e-shopping experience more natural, attractive, and fun for buyers. Unfortunately, usability of these interfaces is a major and still unexplored issue. In this paper, we present the approach we are following to guarantee and increase the usability of VR stores, also providing two practical examples of the solutions we are studying. In particular, the last part of the paper is devoted to discuss in detail how our VR store can be extended to 1-to-1 e-commerce applications.