Two probes consisting of vitamin B12 (CNCbl) conjugated to Gd chelates by esterification of the ribose 5’-OH moiety, Gd–DTPA–CNCbl (1; DTPA=diethylenetriamine- N,N,N’,N’’,N’’-pentaacetic acid) and Gd–TTHA–CNCbl (2; TTHA=tri- ACHTUNGTRENUNGethylenetetramine-N,N,N’,N’’,N’’’,N’’’- hexaacetic acid), have been synthesised and characterised.