The role of adenosine A3 receptor activation during ischaemia-like conditions produced byoxy gen and glucose deprivation (OGD) was evaluated with extracellular recordings from the CA1 region of rat hippocampal slices. In all, 7 min of OGD evoked tissue anoxic depolarisation (AD, peak atB7 min from OGD start, n1⁄420) and were invariablyfollowed byirreversible loss of electrically evoked field epsps (fepsps, n1⁄442).
