Peripheral neuropathy is the most common symptom in patients with HCV-associated mixed cryoglobulinemia., in whom it may be the first clinical manifestation. Very frequently, the medical therapy proposed to treat HCV and cryoglobulinaemia and causes an exacerbation of disabling neuropathy. Therefore, other treatment options have been proposed to treat neuropathy, such as alternative immunosuppressive agents(steroids or cyclosporine) and plasma exchange, which have yielded inconsistent results, according to case reports and presumably exert only temporary effects as they do not promote clearance of HCV. We present five cases of cryoglobulinaemia-related neuropathy resistant to steroids and Gabapentin. Oxcarbazepine was introduced and produced moderate and persistent relief of symptoms without side effects.
