Logo del repository
  1. Home
 
Opzioni

Transcutaneous spinal cord direct current stimulation inhibits the lower limb nociceptive flexion reflex in human beings

Cogiamanian, Filippo
•
Vergari, Maurizio
•
Schiaffi, Elena
altro
Priori, Alberto
2011
  • journal article

Periodico
PAIN
Abstract
Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2mA, 15min) applied on the skin overlying the thoracic spinal cord on the lower-limb flexion reflex in a group of 11 healthy volunteers. To investigate whether transcutaneous spinal cord DC stimulation (tsDCS) acts indirectly on the nociceptive reflex by modulating excitability in mono-oligosynaptic segmental reflex pathways, we also evaluated the H-reflex size from soleus muscle after tibial nerve stimulation. In our healthy subjects, anodal thoracic tsDCS reduced the total lower-limb flexion reflex area by 40.25% immediately after stimulation (T0) and by 46.9% 30min after stimulation offset (T30). When we analyzed the 2 lower-limb flexion reflex components (RII tactile and RIII nociceptive) separately, we found that anodal tsDCS induced a significant reduction in RIII area with a slight but not significant effect on RII area. After anodal tsDCS, the RIII area decreased by 27% at T0 and by 28% at T30. Both sham and active tsDCS left all the tested H-reflex variables unchanged. None of our subjects reported adverse effects after active stimulation. These results suggest that tsDCS holds promise as a tool that is complementary or alternative to drugs and invasive spinal cord electrical stimulation for managing pain. Thoracic transcutaneous direct current stimulation induces depression of nociceptive lower limb flexion reflex in human beings that persists after stimulation offset; this form of stimulation holds promise as a tool that is complementary or alternative to drugs and invasive spinal cord electrical stimulation for managing pain.
DOI
10.1016/j.pain.2010.10.041
WOS
WOS:000286192000023
Archivio
http://hdl.handle.net/11368/2836432
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-78651507389
Diritti
metadata only access
Soggetti
  • Direct current stimul...

  • Lower limb flexion re...

  • Pain treatment

  • Spinal cord

  • Spinal cord stimulati...

  • tDCS

  • tsDCS

  • Adult

  • Cross-Over Studie

  • Double-Blind Method

  • Female

  • Human

  • Leg

  • Male

  • Neural Inhibition

  • Pain

  • Reflex

  • Spinal Cord

  • Transcutaneous Electr...

  • Young Adult

  • Pain Management

  • Neurology (clinical)

  • Anesthesiology and Pa...

  • Neurology

  • Pharmacology

Web of Science© citazioni
92
Mese scorso
2
Data di acquisizione
Mar 5, 2024
Visualizzazioni
3
Data di acquisizione
Apr 19, 2024
Vedi dettagli
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback