Karyotypes of Saccharomyces cerevisae SS1189 strain adapted up to 80 ppm Cu2+ and of S. cerevisiae SS189 strain were studied. data demonstrated that both karyotypes were different. After fifty subsequent inocula in the copper-free YNPG broth, chromosomal banding patterns of S. cerevisiae SS1189 strains adapted to Cu2+ did not change. In addition the growth rate in YNPG with copper added, was maintained, too. This result is not in agree with the ones cited in literature.