The category ASC-US continues to be controversial despite strict criteria laid down by the Bethesda 2011 Committee,as it does not have a histological counterpart and it refers to cythological findings that may or may not be associated with a significant epithelial lesion of the cervix. The proportion of CIN2+ is very low among women with an ASC-US diagnosis, so identification of those at higher risk would be clinically useful. In this study we analysed ASC-US cases of Trieste and Gorizia diagnosed in the period 2009-2011 to evaluate the presence/absence of lesions in the histological follow-up in women HR-HPV positives.