The contribution is aimed at providing some introductory remarks on the notion of interculturalidadin Latin America from a legal perspective, starting from a reflection on the specialized literature on the matter (§ 2) and then moving to its articulation in the context of the Organization of American States and in the constitutional system of Ecuador, which is a plurinational and intercultural State. The legal implications of this concept will be outlined through the analysis of the 2016 American Declaration on the Rights of Indigenous Peoples (§ 3) and the jurisprudence of the Inter-American Court of Human Rights (§ 4). The Ecuadorian legal system will be examined on the basis of its constitutional design and on the intercultural approach formalized in some decisions of the Constitutional Court (§ 5).