This paper focuses on the valuation of refurbishment costs for healthcare facilities. The
determination of the more reliable approach for experimental verification is a research topic of great
interest, especially because previous literature on the matter is limited. This study examines ex-ante
cost valuations in the refurbishment of healthcare buildings while using similarity to estimate the
costs that are based on the amount of already accomplished renovations. The methodology involved
a desk analysis deter-mining the technical valuation of intervention needs, and similarity coefficient
applications providing a refurbishment cost valuation. The application was conducted in the
Friuli—Venezia Giulia Region in Italy, where hospitals show structural, layout, and plants deficits
with respect to current regulations, and a technical deepening to identify critical issues is required
to prepare a multi-year intervention plan. The case study results showed that this procedure
requires little initial information to run analyses and its application can support investment budget
planning purposes.