Home
Esportazione
Statistica
Opzioni
Visualizza tutti i metadati (visione tecnica)
Influence of oral conditions on colonization by highly toxigenic Staphylococcus aureus strains
Claudio Passariello
•
M. Puttini
•
Valerio Iebba
altro
P. Gigola
2012
journal article
Periodico
ORAL DISEASES
Abstract
Objectives: As the oral cavity is regarded as a relevant site for Staphylococcus aureus colonization and interhuman transmission, this study aimed to investigate whether different oral conditions influence the rates of S. aureus oral carriage and genetic characters of S. aureus isolates. Subjects and methods: Staphylococcus aureus was searched in samples collected from cheek, gingival margin, and anterior nares of 45 healthy subjects, 27 periodontitis affected subjects, and 29 subjects with fixed prosthetic restorations. Isolates were screened for 17 genetic determinants, and Partial Least Square Discriminant Analysis was performed to evaluate whether specific characters correlated with oral condition or site of isolation. Results: The three subject groups showed comparable nasal carriage rates but, both the periodontitis and prosthetic restoration groups showed significantly higher oral carriage rates, as compared to healthy subjects (P=0.01 and 0.02, respectively). Moreover, periodontitis affected subjects hosted strains possessing a distinct genotypic and phenotypic background, characterized by the presence of a larger number of exotoxins encoding genes. Conclusions: These data confirm that the oral cavity is an important site of S. aureus colonization and demonstrate that conditions modifying the oral environment, as the presence of periodontitis and of fixed prosthetic restorations, promote S. aureus carriage and may favor the spread of more pathogenic strains. © 2011 John Wiley & Sons A/S.
DOI
10.1111/j.1601-0825.2011.01889.x
WOS
WOS:000302003800010
SCOPUS
2-s2.0-84859109385
Archivio
http://hdl.handle.net/11368/2956614
http://www.scopus.com/inward/record.url?eid=2-s2.0-84859109385&partnerID=65&md5=a75a44f8ae3ff74df30b58379b22336d
Diritti
metadata only access
Soggetti
periodontitis
fixed prosthesis
oral carriage
staphylococcus aureus...
nasal carriage
Web of Science© citazioni
20
Data di acquisizione
Mar 28, 2024
google-scholar
Vedi dettagli