Hepatocellular carcinoma (HCC) is the predominant
form of primary liver cancer and represents the third
leading cause of cancer-related death worldwide.
Current available therapeutic approaches are poorly
effective, especially for the advanced forms of the
disease. In the last year, short double stranded RNA
molecules termed small interfering RNAs (siRNAs) and
micro interfering RNAs (miRNA), emerged as interesting
molecules with potential therapeutic value for HCC.
The practical use of these molecules is however limited
by the identification of optimal molecular targets and
especially by the lack of effective and targeted HCC
delivery systems. Here we focus our discussion on the
most recent advances in the identification of siRNAs/
miRNAs molecular targets and on the development of
suitable siRNA/miRNAs delivery systems.
