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Cholinergic Stimulation Enhances Bayesian Belief Updating in the Deployment of Spatial Attention

Vossel, S.
•
Bauer, M.
•
Adams, R. A.
altro
Mathys, Christoph Daniel
2014
  • journal article

Periodico
THE JOURNAL OF NEUROSCIENCE
Abstract
The exact mechanisms whereby the cholinergic neurotransmitter system contributes to attentional processing remain poorly understood. Here, we applied computational modeling to psychophysical data (obtained from a spatial attention task) under a psychopharmacological challenge with the cholinesterase inhibitor galantamine (Reminyl). This allowed us to characterize the cholinergic modulation of selective attention formally, in terms of hierarchical Bayesian inference. In a placebo-controlled, within-subject, crossover design, 16 healthy human subjects performed a modified version of Posner's location-cueing task in which the proportion of validly and invalidly cued targets (percentage of cue validity, % CV) changed over time. Saccadic response speeds were used to estimate the parameters of a hierarchical Bayesian model to test whether cholinergic stimulation affected the trial-wise updating of probabilistic beliefs that underlie the allocation of attention or whether galantamine changed the mapping from those beliefs to subsequent eye movements. Behaviorally, galantamine led to a greater influence of probabilistic context (% CV) on response speed than placebo. Crucially, computational modeling suggested this effect was due to an increase in the rate of belief updating about cue validity (as opposed to the increased sensitivity of behavioral responses to those beliefs). We discuss these findings with respect to cholinergic effects on hierarchical cortical processing and in relation to the encoding of expected uncertainty or precision. © 2014 the authors.
DOI
10.1523/JNEUROSCI.0091-14.2014
WOS
WOS:000345907500022
Archivio
http://hdl.handle.net/20.500.11767/47858
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84911407412
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236403/
Diritti
open access
Soggetti
  • Acetylcholine

  • Bayesian inference

  • Saccade

  • Spatial attention

  • Settore M-PSI/02 - Ps...

Scopus© citazioni
35
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Web of Science© citazioni
46
Data di acquisizione
Mar 28, 2024
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
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