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SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome

Turolo, Stefano
•
Edefonti, Alberto
•
Lepore, Marta
altro
Montini, Giovanni
2016
  • journal article

Periodico
PHARMACOGENOMICS
Abstract
AIM: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. PATIENTS & METHODS: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. RESULTS: Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. CONCLUSION: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.
DOI
10.2217/pgs-2016-0029
WOS
WOS:000379837800004
Archivio
http://hdl.handle.net/11368/2880327
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979578250
http://www.futuremedicine.com/doi/abs/10.2217/pgs-2016-0029?journalCode=pgs
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2880327
Soggetti
  • SXR

  • idiopathic nephrotic ...

  • steroid-resistant

  • steroids

Scopus© citazioni
7
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
7
Data di acquisizione
Mar 19, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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