The contemporary dynamics impose companies to both innovate and internationalize at the same time while remaining competitive in the international marketplace. With this context in mind, Industry 4.0 technologies have the potential to increase the competitiveness of companies, leading to a new era of “Manufacturing Renaissance.” Recently, conceptual studies have speculated on possible impacts of the adoption of Industry 4.0 technologies in terms of international business. However, empirical studies on this topic are still lacking. Through a multiple case study approach, this study presents exploratory qualitative research investigating the relationship between Industry 4.0 and the internationalization of companies. The analysis of 16 Italian manufacturing exporting companies, which have adopted some of these technologies, has revealed a more intriguing relationship compared to the one presented in current literature, and thus has opened avenues for future research on this issue.