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Metabolic scaling in solid tumours

MILOTTI, EDOARDO
•
V. Vyshemirsky
•
M. Sega
altro
R. Chignola
2013
  • journal article

Periodico
SCIENTIFIC REPORTS
Abstract
Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. Recently, by combining the diffusion of oxygen, nutrients, and metabolites in the extracellular environment, and the internal motions that mix live and dead cells, we derived a growth law of solid tumours which is linked to parameters at the cellular level1. Here we use this growth law to obtain a metabolic scaling law for solid tumours, which is obeyed by tumours of different histotypes both in vitro and in vivo, and we display its relation with the fractal dimension of the distribution of live cells in the tumour mass. The scaling behaviour is related to measurable parameters, with potential applications in the clinical practice.
DOI
10.1038/srep01938
WOS
WOS:000319797000004
Archivio
http://hdl.handle.net/11368/2706637
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84899743820
http://www.nature.com/srep/2013/130603/srep01938/full/srep01938.html
Diritti
metadata only access
Soggetti
  • Power law

  • Cancer metabolism

  • Cancer model

  • Biological physics

Web of Science© citazioni
12
Data di acquisizione
Mar 25, 2024
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